About SwanBio Therapeutics

SwanBio is a privately held, newly established biotechnology company focused on the discovery and development of innovative gene therapy products for the treatment of central nervous system (CNS) disorders and diseases. SwanBio has a deeply experienced leadership team and is building an open, innovative culture that trusts its people, processes and science to deliver scientific, clinical, and business success. SwanBio’s lead investor is Syncona, a premiere investment partner focused on building companies delivering transformational healthcare treatments. Syncona has a deep pool of capital and they are established leaders in the development of genetic medicines. In particular, they present a legacy of success in long term investment strategies for companies in the Gene and Cell Therapy space. Our goal is to become a world-leader in treating neurodegenerative diseases. With locations in Philadelphia and Boston, the SwanBio Team is building a strong pipeline of gene therapy development programs with a directed focus on critical unmet medical needs for CNS diseases. SwanBio offers all team members both competitive compensation and benefits.

The Opportunity

We are seeking a highly motivated biochemist to join our Target Validation group and play a critical role in characterization of therapeutic transgene quantities, expressed transgene protein, and development of biochemical reagents related to our gene therapy pipeline. The position offers an exciting opportunity to engage in the discovery and development of Biotherapeutics for unmet medical needs.

Key Responsibilities
In this role you will:

• Process biological samples for extraction of target proteins and downstream assays
• Perform protein characterization including protein quantitation, Western blotting, SDS-PAGE, WES/JESS, ELISA, and immunoprecipitation
• Perform mammalian cell culture and transfection
• Perform genomic DNA extraction and PCR (ddPCR preferred)
• Produce recombinant proteins in prokaryotic and eukaryotic expression systems
• Assist in the design and execution of non-routine experiments in an efficient and independent manner
• Demonstrate the ability to interpret outcome of experiments and to propose appropriate follow-up
• Report and treat data with a high level of integrity and ethics
• Troubleshoot problems as needed
• Participate in cross-function initiatives as needed
• Independently present/defend scientific findings in project team or Department meetings
• Perform literature searches and extract relevant information from published protocols
• Communicate own work effectively orally and in writing
• Contribute to writing protocols, procedures, and technical reports; provide input for scientific reports
• Comply with applicable regulations and perform all work in a safe manner
• Maintain proper records in accordance with SOPs and policies

Basic Requirements:

• BS degree in biochemistry, molecular biology, neuroscience or a related discipline plus at least 5 years’ relevant experience OR a Masters’ Degree plus at least 3 years’ relevant experience (preferably in an industry setting)
• Hands-on experience in Protein Characterization techniques such as quantitation, SDS-PAGE, immunoprecipitation, western blotting, ELISA
• Knowledge of DNA extraction methods, quantitation, and PCR
• Previous protein expression and at least affinity-purification experience
• Experience in cell line maintenance
• Working knowledge of neurobiology preferred
• Ability to concisely and accurately report technical data and information
• Ability to troubleshoot and correct problems
• Appropriate level of understanding of applicable regulations
• Experience with oversight of CROs preferred

Skills:

• Excellent written and verbal communication skills
• Outstanding problem-solving skills
• Ability to be highly productive in a fluid, fast-paced and team-oriented work environment
• Strong collaboration and team-working skills
• Strong interpersonal and organizational skills
• Proven ability to work independently and effectively plan and organize work activities and prioritize task completion to meet deadlines
• Possess a mindset of no job too large or too small.

About the Benefits:

The successful candidate will enjoy a competitive base salary and the opportunity to participate in incentive compensation programs including bonus and stock option plans. Additionally, SwanBio Therapeutics offers all team members a comprehensive benefits program including medical, dental, vision care, 401(k), paid vacation and holiday time.

SwanBio Therapeutics is an equal opportunity employer